Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell immunotherapy. Despite its promising activity, bryostatin 1 is neither evolved nor optimized for the treatment of human disease. Here we report t...

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Detalles Bibliográficos
Autores principales: Hardman, Clayton, Ho, Stephen, Shimizu, Akira, Luu-Nguyen, Quang, Sloane, Jack L., Soliman, Mohamed S. A., Marsden, Matthew D., Zack, Jerome A., Wender, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170889/
https://www.ncbi.nlm.nih.gov/pubmed/32312992
http://dx.doi.org/10.1038/s41467-020-15742-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170889/
https://www.ncbi.nlm.nih.gov/pubmed/32312992
http://dx.doi.org/10.1038/s41467-020-15742-7

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