Cargando…

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell immunotherapy. Despite its promising activity, bryostatin 1 is neither evolved nor optimized for the treatment of human disease. Here we report t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hardman, Clayton, Ho, Stephen, Shimizu, Akira, Luu-Nguyen, Quang, Sloane, Jack L., Soliman, Mohamed S. A., Marsden, Matthew D., Zack, Jerome A., Wender, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170889/ https://www.ncbi.nlm.nih.gov/pubmed/32312992 http://dx.doi.org/10.1038/s41467-020-15742-7

Ejemplares similares

Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal
por: Moran, Jose A., et al.
Publicado: (2023)

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents
por: Marsden, Matthew D., et al.
Publicado: (2018)

Tracking HIV Rebound following Latency Reversal Using Barcoded HIV
por: Marsden, Matthew D., et al.
Publicado: (2020)

Designed, Synthetically Accessible Bryostatin Analogues Potently Induce Activation of Latent HIV Reservoirs in vitro
por: DeChristopher, Brian A., et al.
Publicado: (2012)

Retrosynthetic Reaction Prediction Using Neural Sequence-to-Sequence Models
por: Liu, Bowen, et al.
Publicado: (2017)

A Gateway Synthesis, PKC Affinities and Cell Growth Activities of Daphnane Congeners
por: Wender, Paul A., et al.
Publicado: (2011)

Function through Synthesis-Informed Design
por: Wender, Paul A., et al.
Publicado: (2015)

In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication
por: Marsden, Matthew D., et al.
Publicado: (2017)

Activation of Latent HIV Using Drug-Loaded Nanoparticles
por: Kovochich, Michael, et al.
Publicado: (2011)

PKCα and PKCδ: Friends and Rivals
por: Black, Jennifer D., et al.
Publicado: (2022)

Leveraging the Treg-intrinsic CTLA4–PKCη signaling pathway for cancer immunotherapy
por: Liu, Hsin-Yu, et al.
Publicado: (2021)

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets
por: Pears, Catherine J., et al.
Publicado: (2008)

Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors
por: Ratnayake, Wishrawana S., et al.
Publicado: (2018)

Bioengineered Vaults: Self-Assembling Protein Shell–Lipophilic Core Nanoparticles for Drug Delivery
por: Buehler, Daniel C., et al.
Publicado: (2014)

Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs
por: Wender, Paul A., et al.
Publicado: (2014)

Role of hepatic PKCβ in nutritional regulation of hepatic glycogen synthesis
por: Shu, Yaoling, et al.
Publicado: (2021)

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination
por: Garcia, Neus, et al.
Publicado: (2019)

Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors
por: Wender, Paul A., et al.
Publicado: (2014)

Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice
por: Pham, Trong Kha, et al.
Publicado: (2023)

Muscle Contraction Regulates BDNF/TrkB Signaling to Modulate Synaptic Function through Presynaptic cPKCα and cPKCβI
por: Hurtado, Erica, et al.
Publicado: (2017)

A cancer-associated, genome protective programme engaging PKCε
por: Parker, Peter J., et al.
Publicado: (2020)

Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation
por: Halder, Kuntal, et al.
Publicado: (2014)

Coordination of glioblastoma cell motility by PKCι
por: Baldwin, R Mitchell, et al.
Publicado: (2010)

PKC decodes Ca(2+)
por: LeBrasseur, Nicole
Publicado: (2006)

PKC and calcium channel trafficking
por: Hofmann, Franz
Publicado: (2017)

PKC and PKN in heart disease
por: Marrocco, Valeria, et al.
Publicado: (2019)

The long and short of PKC modulation of the L-type calcium channel
por: Satin, Jonathan
Publicado: (2013)

Latency reversal plus natural killer cells diminish HIV reservoir in vivo
por: Kim, Jocelyn T., et al.
Publicado: (2022)

Inhibition of PKC disrupts addiction-related memory
por: Howell, Kristin K., et al.
Publicado: (2014)

Design, synthesis, and docking studies of novel pyrazole-based scaffolds and their evaluation as VEGFR2 inhibitors in the treatment of prostate cancer
por: Soliman, Dalia H., et al.
Publicado: (2023)

Design, synthesis and bioevaluation of novel 6-substituted aminoindazole derivatives as anticancer agents
por: Hoang, Ngo Xuan, et al.
Publicado: (2020)

RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice
por: Shimizu, Saki, et al.
Publicado: (2015)

Increase in PKCα Activity during Heart Failure Despite the Stimulation of PKCα Braking Mechanism
por: Aslam, Naveed
Publicado: (2020)

Alcohol Dependence Modulates Amygdalar mTORC2 and PKCε Expression in a Rodent Model
por: Hanim, Athirah, et al.
Publicado: (2023)

Pkc-Mediated Stimulation of Amphibian Cftr Depends on a Single Phosphorylation Consensus Site. Insertion of This Site Confers Pkc Sensitivity to Human Cftr
por: Button, Brian, et al.
Publicado: (2001)

Role of Immunotherapy in Pulmonary Angiosarcoma: A Case Report
por: Nguyen, Quang Tien, et al.
Publicado: (2021)

Design, synthesis, structure, in vitro cytotoxic activity evaluation and docking studies on target enzyme GSK-3β of new indirubin-3ʹ-oxime derivatives
por: Dan, Nguyen Trong, et al.
Publicado: (2020)

Intervention of PKC-θ as an immunosuppressive regimen
por: Sun, Zuoming
Publicado: (2012)

PKCδ Blues for the β-Cell
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2010)

Atypical PKC: therapeutic target for Alzheimer’s?
por: Farese, Robert V., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8kh0tkab8otpa6gd2nol9g85i1