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The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants
Plant halogenated natural products are rare and harbor various interesting bioactivities, yet the biochemical basis for the involved halogenation chemistry is unknown. While a handful of Fe(II)- and 2-oxoglutarate-dependent halogenases (2ODHs) have been found to catalyze regioselective halogenation...
Autores principales: | Kim, Colin Y., Mitchell, Andrew J., Glinkerman, Christopher M., Li, Fu-Shuang, Pluskal, Tomáš, Weng, Jing-Ke |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170919/ https://www.ncbi.nlm.nih.gov/pubmed/32313070 http://dx.doi.org/10.1038/s41467-020-15777-w |
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