Variable Assembly of EMRE and MCU Creates Functional Channels with Distinct Gatekeeping Profiles

MCU is a Ca(2+)-selective channel that mediates mitochondrial Ca(2+) influx. The human channel contains tetrameric pore-forming MCU, regulatory subunits MICU1/2, and EMRE that is required both for channel function and MICU1/2-mediated Ca(2+) regulation. A structure of MCU with EMRE revealed a 4:4 st...

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Detalles Bibliográficos
Autores principales: Payne, Riley, Li, Carmen, Foskett, J. Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170992/
https://www.ncbi.nlm.nih.gov/pubmed/32315830
http://dx.doi.org/10.1016/j.isci.2020.101037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170992/
https://www.ncbi.nlm.nih.gov/pubmed/32315830
http://dx.doi.org/10.1016/j.isci.2020.101037

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