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Variable Assembly of EMRE and MCU Creates Functional Channels with Distinct Gatekeeping Profiles
MCU is a Ca(2+)-selective channel that mediates mitochondrial Ca(2+) influx. The human channel contains tetrameric pore-forming MCU, regulatory subunits MICU1/2, and EMRE that is required both for channel function and MICU1/2-mediated Ca(2+) regulation. A structure of MCU with EMRE revealed a 4:4 st...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170992/ https://www.ncbi.nlm.nih.gov/pubmed/32315830 http://dx.doi.org/10.1016/j.isci.2020.101037 |