NOXA-dependent contextual synthetic lethality of BCL-XL inhibition and “osmotic reprogramming” in colorectal cancer

A sophisticated network of BCL-2 family proteins regulates the mitochondria-associated (intrinsic) apoptosis pathway. Antiapoptotic members such as BCL-XL or MCL-1 safeguard the outer mitochondrial membrane and prevent accidental cell death in a functionally redundant and/or compensatory manner. How...

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Detalles Bibliográficos
Autores principales: Knoll, Gertrud, Riffelsberger, Petra, Raats, Danielle, Kranenburg, Onno, Ehrenschwender, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171071/
https://www.ncbi.nlm.nih.gov/pubmed/32312973
http://dx.doi.org/10.1038/s41419-020-2446-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171071/
https://www.ncbi.nlm.nih.gov/pubmed/32312973
http://dx.doi.org/10.1038/s41419-020-2446-8

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