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Measurement and models accounting for cell death capture hidden variation in compound response

Cancer cell sensitivity or resistance is almost universally quantified through a direct or surrogate measure of cell number. However, compound responses can occur through many distinct phenotypic outcomes, including changes in cell growth, apoptosis, and non-apoptotic cell death. These outcomes have...

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Detalles Bibliográficos
Autores principales: Bae, Song Yi, Guan, Ning, Yan, Rui, Warner, Katrina, Taylor, Scott D., Meyer, Aaron S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171175/
https://www.ncbi.nlm.nih.gov/pubmed/32312951
http://dx.doi.org/10.1038/s41419-020-2462-8