RAC1-Dependent ORAI1 Translocation to the Leading Edge Supports Lamellipodia Formation and Directional Persistence

Tumor invasion requires efficient cell migration, which is achieved by the generation of persistent and polarized lamellipodia. The generation of lamellipodia is supported by actin dynamics at the leading edge where a complex of proteins known as the WAVE regulatory complex (WRC) promotes the requir...

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Detalles Bibliográficos
Autores principales: Lopez-Guerrero, Aida M., Espinosa-Bermejo, Noelia, Sanchez-Lopez, Irene, Macartney, Thomas, Pascual-Caro, Carlos, Orantos-Aguilera, Yolanda, Rodriguez-Ruiz, Lola, Perez-Oliva, Ana B., Mulero, Victoriano, Pozo-Guisado, Eulalia, Martin-Romero, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171199/
https://www.ncbi.nlm.nih.gov/pubmed/32313105
http://dx.doi.org/10.1038/s41598-020-63353-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171199/
https://www.ncbi.nlm.nih.gov/pubmed/32313105
http://dx.doi.org/10.1038/s41598-020-63353-5

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