Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [(14)C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (QWBA) study conducted in male Long‐Evans rats. Plasma...

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Detalles Bibliográficos
Autores principales: Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171252/
https://www.ncbi.nlm.nih.gov/pubmed/32314550
http://dx.doi.org/10.1002/prp2.579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171252/
https://www.ncbi.nlm.nih.gov/pubmed/32314550
http://dx.doi.org/10.1002/prp2.579

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