Cargando…
Modelling of pH-dependence to develop a strategy for stabilising mAbs at acidic steps in production
Engineered proteins are increasingly being required to function or pass through environmental stresses for which the underlying protein has not evolved. A major example in health are antibody therapeutics, where a low pH step is used for purification and viral inactivation. In order to develop a com...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171260/ https://www.ncbi.nlm.nih.gov/pubmed/32322371 http://dx.doi.org/10.1016/j.csbj.2020.03.002 |