FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma

FAM46C, frequently mutated in multiple myeloma (MM), has recently been shown to encode a non‐canonical poly(A) polymerase (ncPAP). However, its target mRNAs and its role in MM pathogenesis remain mostly unknown. Using CRISPR‐Cas9 technology and gene expression analysis, we found that the inactivatio...

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Detalles Bibliográficos
Autores principales: Herrero, Ana Belén, Quwaider, Dalia, Corchete, Luis Antonio, Mateos, Maria Victoria, García‐Sanz, Ramón, Gutiérrez, Norma C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171423/
https://www.ncbi.nlm.nih.gov/pubmed/32141701
http://dx.doi.org/10.1111/jcmm.15078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171423/
https://www.ncbi.nlm.nih.gov/pubmed/32141701
http://dx.doi.org/10.1111/jcmm.15078

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