Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors

Herein we report a series of novel chloramphenicol amine derivatives as aminopeptidase N (APN)/CD13 inhibitors. All compounds were synthesized starting from commercially available (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol. The preliminary biological screening showed that some compounds exhi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Kanghui, Wang, Qiang, Su, Li, Fang, Hao, Wang, Xuejian, Gong, Jianzhi, Wang, Binghe, Xu, Wenfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172530/
https://www.ncbi.nlm.nih.gov/pubmed/19423354
http://dx.doi.org/10.1016/j.bmc.2009.04.038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172530/
https://www.ncbi.nlm.nih.gov/pubmed/19423354
http://dx.doi.org/10.1016/j.bmc.2009.04.038

Ejemplares similares