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α(1)-Antitrypsin and the serpins: variation and countervariation
α(1)-Antitrypsin is a plasma protein which protects elastic tissue from proteolytic attack. Consequently, genetic deficiency, or the oxidation of its reactive centre in cigarette smokers can result in the degenerative lung disease emphysema. Structural studies explain the mechanisms involved and hav...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Published by Elsevier Ltd.
1985
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172600/ http://dx.doi.org/10.1016/0968-0004(85)90011-8 |