Analysis of helicase domain mutations in the hepatitis E virus derived from patients with fulminant hepatic failure: Effects on enzymatic activities and virus replication

Fulminant hepatic failure (FHF) is the severe form of hepatitis E virus infection. Virus sequence analyses from severe cases have shown presence of unique and highly conserved mutations in the helicase domain of genotype 1, 3 and 4 viruses. We evaluated role of two amino acid replacements (L1110F) a...

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Detalles Bibliográficos
Autores principales: Devhare, Pradip, Sharma, Kavyanjali, Mhaindarkar, Vaibhav, Arankalle, Vidya, Lole, Kavita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172619/
https://www.ncbi.nlm.nih.gov/pubmed/24630891
http://dx.doi.org/10.1016/j.virusres.2014.02.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172619/
https://www.ncbi.nlm.nih.gov/pubmed/24630891
http://dx.doi.org/10.1016/j.virusres.2014.02.018

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