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Error thresholds and the constraints to RNA virus evolution
RNA viruses are often thought of as possessing almost limitless adaptability as a result of their extreme mutation rates. However, high mutation rates also put a cap on the size of the viral genome by establishing an error threshold, beyond which lethal numbers of deleterious mutations accumulate. H...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Ltd.
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172642/ https://www.ncbi.nlm.nih.gov/pubmed/14659685 http://dx.doi.org/10.1016/j.tim.2003.10.006 |