Aspartic acid at residue 185 modulates the capacity of HP-PRRSV nsp4 to antagonize IFN-I expression

In a previous study, we have shown that highly-pathogenic PRRSV (HP-PRRSV) nonstructural protein 4 (nsp4) antagonizes type I IFN expression induced by poly(I:C). Here, we demonstrated that the mutation of Aspartic acid 185 (Asp185) impaired the ability of nsp4 to inhibit IFN-I production induced by...

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Detalles Bibliográficos
Autores principales: Wei, Ze-yu, Liu, Fang, Li, Yu, Wang, Hong-lei, Zhang, Zi-ding, Chen, Zhong-zhou, Feng, Wen-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172695/
https://www.ncbi.nlm.nih.gov/pubmed/32452419
http://dx.doi.org/10.1016/j.virol.2020.04.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172695/
https://www.ncbi.nlm.nih.gov/pubmed/32452419
http://dx.doi.org/10.1016/j.virol.2020.04.007

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