Viral proteases as targets for chemotherapeutic intervention

Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent peptide-mimetic inhibitors have been developed....

Descripción completa

Detalles Bibliográficos
Autores principales: Hellen, Christopher U.T., Wimmer, Eckard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1992
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172713/
https://www.ncbi.nlm.nih.gov/pubmed/1369416
http://dx.doi.org/10.1016/0958-1669(92)90010-G
_version_ 1783524309959966720
author Hellen, Christopher U.T.
Wimmer, Eckard
author_facet Hellen, Christopher U.T.
Wimmer, Eckard
author_sort Hellen, Christopher U.T.
collection PubMed
description Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent peptide-mimetic inhibitors have been developed. Techniques and strategies used to improve the efficiency of these compounds are likely to be applicable to other viral proteinases.
format Online
Article
Text
id pubmed-7172713
institution National Center for Biotechnology Information
language English
publishDate 1992
publisher Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-71727132020-04-22 Viral proteases as targets for chemotherapeutic intervention Hellen, Christopher U.T. Wimmer, Eckard Curr Opin Biotechnol Article Many viruses encode proteinases that are essential for infectivity, and are consequently attractive chemotherapeutic targets. The biochemistry and structure of the human immunodeficiency virus proteinase have been characterized extensively, and potent peptide-mimetic inhibitors have been developed. Techniques and strategies used to improve the efficiency of these compounds are likely to be applicable to other viral proteinases. Published by Elsevier Ltd. 1992-12 2004-08-26 /pmc/articles/PMC7172713/ /pubmed/1369416 http://dx.doi.org/10.1016/0958-1669(92)90010-G Text en Copyright © 1992 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hellen, Christopher U.T.
Wimmer, Eckard
Viral proteases as targets for chemotherapeutic intervention
title Viral proteases as targets for chemotherapeutic intervention
title_full Viral proteases as targets for chemotherapeutic intervention
title_fullStr Viral proteases as targets for chemotherapeutic intervention
title_full_unstemmed Viral proteases as targets for chemotherapeutic intervention
title_short Viral proteases as targets for chemotherapeutic intervention
title_sort viral proteases as targets for chemotherapeutic intervention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172713/
https://www.ncbi.nlm.nih.gov/pubmed/1369416
http://dx.doi.org/10.1016/0958-1669(92)90010-G
work_keys_str_mv AT hellenchristopherut viralproteasesastargetsforchemotherapeuticintervention
AT wimmereckard viralproteasesastargetsforchemotherapeuticintervention

Ejemplares similares