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Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor
A series of phosphinic compounds mimicking the transition state of substrates hydrolysed by aminopeptidase N (EC 3.4.11.2) were synthesized. These new compounds have potent inhibitory activities with Ki values in the nanomolar range. These derivatives behave as the most potent APN inhibitors designe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Published by Elsevier Ltd.
1999
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172755/ https://www.ncbi.nlm.nih.gov/pubmed/10386926 http://dx.doi.org/10.1016/S0960-894X(99)00219-X |