An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors

We have solved the crystal and molecular structures of hepatitis A viral (HAV) 3C proteinase, a cysteine peptidase having a chymotrypsin-like protein fold, in complex with each of three tetrapeptidyl-based methyl ketone inhibitors to resolutions beyond 1.4 Å, the highest resolution to date for a 3C...

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Detalles Bibliográficos
Autores principales: Yin, Jiang, Cherney, Maia M., Bergmann, Ernst M., Zhang, Jianmin, Huitema, Carly, Pettersson, Hanna, Eltis, Lindsay D., Vederas, John C., James, Michael N.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172884/
https://www.ncbi.nlm.nih.gov/pubmed/16860823
http://dx.doi.org/10.1016/j.jmb.2006.06.047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172884/
https://www.ncbi.nlm.nih.gov/pubmed/16860823
http://dx.doi.org/10.1016/j.jmb.2006.06.047

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