Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus

2-α-Thiomethylmercuryl 9-acetamido-9-deoxy-sialoside was prepared and found to inhibit the 9-O-acetylsialic acid esterase from influenza C virus in a competitive manner with a K(i) of 4.2±0.5 mM. The inhibitor is being used in the X-ray determination of the crystal structure of the esterase.

Detalles Bibliográficos
Autores principales: Fitz, Wolfgang, Rosenthal, Peter B., Wong, Chi-Huey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172942/
https://www.ncbi.nlm.nih.gov/pubmed/8879557
http://dx.doi.org/10.1016/0968-0896(96)00123-X
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author Fitz, Wolfgang
Rosenthal, Peter B.
Wong, Chi-Huey
author_facet Fitz, Wolfgang
Rosenthal, Peter B.
Wong, Chi-Huey
author_sort Fitz, Wolfgang
collection PubMed
description 2-α-Thiomethylmercuryl 9-acetamido-9-deoxy-sialoside was prepared and found to inhibit the 9-O-acetylsialic acid esterase from influenza C virus in a competitive manner with a K(i) of 4.2±0.5 mM. The inhibitor is being used in the X-ray determination of the crystal structure of the esterase.
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spelling pubmed-71729422020-04-22 Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus Fitz, Wolfgang Rosenthal, Peter B. Wong, Chi-Huey Bioorg Med Chem Article 2-α-Thiomethylmercuryl 9-acetamido-9-deoxy-sialoside was prepared and found to inhibit the 9-O-acetylsialic acid esterase from influenza C virus in a competitive manner with a K(i) of 4.2±0.5 mM. The inhibitor is being used in the X-ray determination of the crystal structure of the esterase. Published by Elsevier Ltd. 1996-08 1998-12-12 /pmc/articles/PMC7172942/ /pubmed/8879557 http://dx.doi.org/10.1016/0968-0896(96)00123-X Text en Copyright © 1996 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Fitz, Wolfgang
Rosenthal, Peter B.
Wong, Chi-Huey
Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus
title Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus
title_full Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus
title_fullStr Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus
title_full_unstemmed Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus
title_short Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the X-ray structure determination of 9-O-acetylsialic acid esterase from influenza C virus
title_sort synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the x-ray structure determination of 9-o-acetylsialic acid esterase from influenza c virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172942/
https://www.ncbi.nlm.nih.gov/pubmed/8879557
http://dx.doi.org/10.1016/0968-0896(96)00123-X
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