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Functional Circularity of Legitimate Qβ Replicase Templates

Qβ replicase (RNA-directed RNA polymerase of bacteriophage Qβ) exponentially amplifies certain RNAs in vitro. Previous studies have shown that Qβ replicase can initiate and elongate on a variety of RNAs; however, only a minute fraction of them are recognized as ‘legitimate’ templates. Guanosine 5′-t...

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Detalles Bibliográficos
Autores principales: Ugarov, Victor I., Chetverin, Alexander B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173182/
https://www.ncbi.nlm.nih.gov/pubmed/18466922
http://dx.doi.org/10.1016/j.jmb.2008.03.074