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JAK2 and Beyond: JAK2V617 Mutational Study of Myeloproliferative Disorders and Haematological Malignancies
BACKGROUND: Janus Tyrosine Kinase-2 (JAK2 V617F), a novel point mutation affecting the MPD’S is a somatic gain-of-function mutation. It alters a highly conserved amino acid valine in the negative regulatory JH2 domain to phenylalanine predicted to dysregulate kinase activity. AIM: To evaluate the pr...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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West Asia Organization for Cancer Prevention
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173381/ https://www.ncbi.nlm.nih.gov/pubmed/31870101 http://dx.doi.org/10.31557/APJCP.2019.20.12.3611 |