LAG3 (LAG-3, CD223) DNA methylation correlates with LAG3 expression by tumor and immune cells, immune cell infiltration, and overall survival in clear cell renal cell carcinoma

BACKGROUND: Lymphocyte activating 3 (LAG3, LAG-3, CD223) is a promising target for immune checkpoint inhibition in clear cell renal cell carcinoma (KIRC). The aim of this study was to investigate the epigenetic regulation of LAG3 in KIRC by methylation. METHODS: We correlated quantitative LAG3 methy...

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Detalles Bibliográficos
Autores principales: Klümper, Niklas, Ralser, Damian J, Bawden, Emma Grace, Landsberg, Jenny, Zarbl, Romina, Kristiansen, Glen, Toma, Marieta, Ritter, Manuel, Hölzel, Michael, Ellinger, Jörg, Dietrich, Dimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Immunotherapy Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174079/
https://www.ncbi.nlm.nih.gov/pubmed/32234847
http://dx.doi.org/10.1136/jitc-2020-000552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174079/
https://www.ncbi.nlm.nih.gov/pubmed/32234847
http://dx.doi.org/10.1136/jitc-2020-000552

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