Mitigation of Tacrolimus-Associated Nephrotoxicity by PLGA Nanoparticulate Delivery Following Multiple Dosing to Mice while Maintaining its Immunosuppressive Activity

The aim of this study was to assess the ability of PLGA nanoparticles (NPs) to reduce the tacrolimus (TAC)-associated nephrotoxicity following multiple dose administration. The mean diameter of prepared NPs was in the range of 227 to 263 nm with an 8.32% drug loading (w/w). Moreover, in vitro releas...

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Detalles Bibliográficos
Autores principales: Alshamsan, Aws, Binkhathlan, Ziyad, Kalam, Mohd Abul, Qamar, Wajhul, Kfouri, Hala, Alghonaim, Mohammed, Lavasanifar, Afsaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174389/
https://www.ncbi.nlm.nih.gov/pubmed/32317681
http://dx.doi.org/10.1038/s41598-020-63767-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174389/
https://www.ncbi.nlm.nih.gov/pubmed/32317681
http://dx.doi.org/10.1038/s41598-020-63767-1

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