Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking specific biologic pathways that drive cancer progression and metastasis. Using a...

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Detalles Bibliográficos
Autores principales: González, Nazareno, Cardama, Georgina A., Chinestrad, Patricio, Robles-Valero, Javier, Rodríguez-Fdez, Sonia, Lorenzo-Martín, L. Francisco, Bustelo, Xosé R., Lorenzano Menna, Pablo, Gomez, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174510/
https://www.ncbi.nlm.nih.gov/pubmed/32351958
http://dx.doi.org/10.3389/fcell.2020.00240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174510/
https://www.ncbi.nlm.nih.gov/pubmed/32351958
http://dx.doi.org/10.3389/fcell.2020.00240

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