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Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D
The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (F(passive)) of cardiomyocytes. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. PKD phosphorylates myofilam...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174613/ https://www.ncbi.nlm.nih.gov/pubmed/32351396 http://dx.doi.org/10.3389/fphys.2020.00240 |