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The Possible Role of Anti-Neu5Gc as an Obstacle in Xenotransplantation

Seventy to ninety percentage of preformed xenoreactive antibodies in human serum bind to the galactose-α(1,3)-galactose Gal epitope, and the creation of Gal knockout (KO) pigs has eliminated hyperacute rejection as a barrier to xenotransplantation. Now other glycan antigens are barriers to move ahea...

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Detalles Bibliográficos
Autores principales: Tector, Alfred Joseph, Mosser, Mathilde, Tector, Matthew, Bach, Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174778/
https://www.ncbi.nlm.nih.gov/pubmed/32351506
http://dx.doi.org/10.3389/fimmu.2020.00622