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Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion

2p16.3 deletions, involving heterozygous NEUREXIN1 (NRXN1) deletion, dramatically increase the risk of developing neurodevelopmental disorders, including autism and schizophrenia. We have little understanding of how NRXN1 heterozygosity increases the risk of developing these disorders, particularly...

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Detalles Bibliográficos
Autores principales: B Hughes, Rebecca, Whittingham-Dowd, Jayde, Simmons, Rachel E, Clapcote, Steven J, Broughton, Susan J, Dawson, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175007/
https://www.ncbi.nlm.nih.gov/pubmed/31812984
http://dx.doi.org/10.1093/cercor/bhz244