Toxic Responses Induced at High Doses May Affect Benchmark Doses

To derive reference points (RPs) for health-based guidance values, the benchmark dose (BMD) approach increasingly replaces the no-observed-adverse-effect level approach. In the BMD approach, the RP corresponds to the benchmark dose lower confidence bounds (BMDLs) of a mathematical dose–response mode...

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Detalles Bibliográficos
Autores principales: Zarn, Jürg A., Zürcher, Ursina A., Geiser, H. Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175069/
https://www.ncbi.nlm.nih.gov/pubmed/32341684
http://dx.doi.org/10.1177/1559325820919605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175069/
https://www.ncbi.nlm.nih.gov/pubmed/32341684
http://dx.doi.org/10.1177/1559325820919605

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