Does Cysteine Rule (CysR) Complete the CendR Principle? Increase in Affinity of Peptide Ligands for NRP-1 Through the Presence of N-Terminal Cysteine

The structure-activity relationship of branched H-Lys(hArg)-Dab-Dhp-Arg-OH sequence analogues, modified with Cys-Asp or Cys at N-terminal amino acids (Lys, hArg), in VEGF-A(165)/Neuropilin-1 complex inhibition is presented. The addition of Cys residue led to a 100-fold decrease in the IC(50) value,...

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Detalles Bibliográficos
Autores principales: Puszko, Anna K., Sosnowski, Piotr, Raynaud, Françoise, Hermine, Olivier, Hopfgartner, Gérard, Lepelletier, Yves, Misicka, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175122/
https://www.ncbi.nlm.nih.gov/pubmed/32183142
http://dx.doi.org/10.3390/biom10030448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175122/
https://www.ncbi.nlm.nih.gov/pubmed/32183142
http://dx.doi.org/10.3390/biom10030448

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