SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence

Melatonin exerts direct neuroprotection against cerebral hypoxic damage, but the mechanisms of its action on microglia have been less characterized. Using both in vitro and in vivo models of hypoxia, we here focused on the role played by silent mating type information regulation 2 homolog 1 (SIRT1)...

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Detalles Bibliográficos
Autores principales: Merlo, Sara, Luaces, Juan Pablo, Spampinato, Simona Federica, Toro-Urrego, Nicolas, Caruso, Grazia Ilaria, D’Amico, Fabio, Capani, Francisco, Sortino, Maria Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175216/
https://www.ncbi.nlm.nih.gov/pubmed/32120833
http://dx.doi.org/10.3390/biom10030364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175216/
https://www.ncbi.nlm.nih.gov/pubmed/32120833
http://dx.doi.org/10.3390/biom10030364

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