Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles

Aberrant extracellular matrix synthesis and remodeling contributes to muscle degeneration and weakness in Duchenne muscular dystrophy (DMD). ADAMTS-5, a secreted metalloproteinase with catalytic activity against versican, is implicated in myogenesis and inflammation. Here, using the mdx mouse model...

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Detalles Bibliográficos
Autores principales: Addinsall, Alex B., Forgan, Leonard G., McRae, Natasha L., Kelly, Rhys W., McDonald, Penny L., McNeil, Bryony, McCulloch, Daniel R., Stupka, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175239/
https://www.ncbi.nlm.nih.gov/pubmed/32156081
http://dx.doi.org/10.3390/biom10030416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175239/
https://www.ncbi.nlm.nih.gov/pubmed/32156081
http://dx.doi.org/10.3390/biom10030416

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