Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis

Hypoxia inducible factors (HIFs) are the key transcription factors that allow cancer cells to survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated ubiquitylation. Unlike sporadic clear‐cell renal carcinomas, VHL mutation is rarely observed in hepatocellular...

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Detalles Bibliográficos
Autores principales: Liu, Xinxin, Zhang, Xiaoli, Peng, Zhiqiang, Li, Chunnan, Wang, Ze, Wang, Chanjuan, Deng, Zhikang, Wu, Bo, Cui, Yu, Wang, Zhanxin, Cui, Chun‐Ping, Zheng, Min, Zhang, Lingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175249/
https://www.ncbi.nlm.nih.gov/pubmed/32328410
http://dx.doi.org/10.1002/advs.201902040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175249/
https://www.ncbi.nlm.nih.gov/pubmed/32328410
http://dx.doi.org/10.1002/advs.201902040

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