The Human RAD5 Homologs, HLTF and SHPRH, Have Separate Functions in DNA Damage Tolerance Dependent on the DNA Lesion Type

Helicase-like transcription factor (HLTF) and SNF2, histone-linker, PHD and RING finger domain-containing helicase (SHPRH), the two human homologs of yeast Rad5, are believed to have a vital role in DNA damage tolerance (DDT). Here we show that HLTF, SHPRH and HLTF/SHPRH knockout cell lines show dif...

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Detalles Bibliográficos
Autores principales: Seelinger, Mareike, Søgaard, Caroline Krogh, Otterlei, Marit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175315/
https://www.ncbi.nlm.nih.gov/pubmed/32192191
http://dx.doi.org/10.3390/biom10030463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175315/
https://www.ncbi.nlm.nih.gov/pubmed/32192191
http://dx.doi.org/10.3390/biom10030463

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