Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences

Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers. This gene silencing frequently occurs due to DNA methylation of the promoter regions, although the u...

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Detalles Bibliográficos
Autores principales: Tramontano, Alfonso, Boffo, Francesca Ludovica, Russo, Giusi, De Rosa, Mariarosaria, Iodice, Ilaria, Pezone, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175352/
https://www.ncbi.nlm.nih.gov/pubmed/32183138
http://dx.doi.org/10.3390/biom10030446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175352/
https://www.ncbi.nlm.nih.gov/pubmed/32183138
http://dx.doi.org/10.3390/biom10030446

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