1H-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Approach to Inhibit HCV-NS3 Protease

The nonstructural (NS) protein NS3/4A protease is a critical factor for hepatitis C virus (HCV) maturation that requires activation by NS4A. Synthetic peptide mutants of NS4A were found to inhibit NS3 function. The bridging from peptide inhibitors to heterocyclic peptidomimetics of NS4A has not been...

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Detalles Bibliográficos
Autores principales: Omar, Abdelsattar M., Elfaky, Mahmoud A., Arold, Stefan T., Soror, Sameh H., Khayat, Maan T., Asfour, Hani Z., Bamane, Faida H., El-Araby, Moustafa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175367/
https://www.ncbi.nlm.nih.gov/pubmed/32245218
http://dx.doi.org/10.3390/biom10030479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175367/
https://www.ncbi.nlm.nih.gov/pubmed/32245218
http://dx.doi.org/10.3390/biom10030479

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