In Vitro Impact of FSH Glycosylation Variants on FSH Receptor-stimulated Signal Transduction and Functional Selectivity

FSH exists as different glycoforms that differ in glycosylation of the hormone-specific β-subunit. Tetra-glycosylated FSH (FSH(24)) and hypo-glycosylated FSH (FSH(18/21)) are the most abundant glycoforms found in humans. Employing distinct readouts in HEK293 cells expressing the FSH receptor, we com...

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Detalles Bibliográficos
Autores principales: Zariñán, Teresa, Butnev, Viktor Y, Gutiérrez-Sagal, Rubén, Maravillas-Montero, José Luis, Martínez-Luis, Iván, Mejía-Domínguez, Nancy R, Juárez-Vega, Guillermo, Bousfield, George R, Ulloa-Aguirre, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175721/
https://www.ncbi.nlm.nih.gov/pubmed/32342021
http://dx.doi.org/10.1210/jendso/bvaa019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175721/
https://www.ncbi.nlm.nih.gov/pubmed/32342021
http://dx.doi.org/10.1210/jendso/bvaa019

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