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Molecular mechanisms of fentanyl mediated β-arrestin biased signaling

The development of novel analgesics with improved safety profiles to combat the opioid epidemic represents a central question to G protein coupled receptor structural biology and pharmacology: What chemical features dictate G protein or β-arrestin signaling? Here we use adaptively biased molecular d...

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Detalles Bibliográficos
Autores principales:	de Waal, Parker W., Shi, Jingjing, You, Erli, Wang, Xiaoxi, Melcher, Karsten, Jiang, Yi, Xu, H. Eric, Dickson, Bradley M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176292/ https://www.ncbi.nlm.nih.gov/pubmed/32275713 http://dx.doi.org/10.1371/journal.pcbi.1007394

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