Everolimus Rescues the Phenotype of Elastin Insufficiency in Patient Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells

OBJECTIVE: Elastin gene deletion or mutation leads to arterial stenoses due to vascular smooth muscle cell (SMC) proliferation. Human induced pluripotent stem cells–derived SMCs can model the elastin insufficiency phenotype in vitro but show only partial rescue with rapamycin. Our objective was to i...

Descripción completa

Detalles Bibliográficos
Autores principales: Kinnear, Caroline, Agrawal, Rahul, Loo, Caitlin, Pahnke, Aric, Rodrigues, Deivid Carvalho, Thompson, Tadeo, Akinrinade, Oyediran, Ahadian, Samad, Keeley, Fred, Radisic, Milica, Mital, Seema, Ellis, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Translational Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176340/
https://www.ncbi.nlm.nih.gov/pubmed/32212852
http://dx.doi.org/10.1161/ATVBAHA.119.313936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176340/
https://www.ncbi.nlm.nih.gov/pubmed/32212852
http://dx.doi.org/10.1161/ATVBAHA.119.313936

Ejemplares similares