Actinobacterial Degradation of 2-Hydroxyisobutyric Acid Proceeds via Acetone and Formyl-CoA by Employing a Thiamine-Dependent Lyase Reaction

The tertiary branched short-chain 2-hydroxyisobutyric acid (2-HIBA) has been associated with several metabolic diseases and lysine 2-hydroxyisobutyrylation seems to be a common eukaryotic as well as prokaryotic post-translational modification in proteins. In contrast, the underlying 2-HIBA metabolis...

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Detalles Bibliográficos
Autores principales: Rohwerder, Thore, Rohde, Maria-Teresa, Jehmlich, Nico, Purswani, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176365/
https://www.ncbi.nlm.nih.gov/pubmed/32351493
http://dx.doi.org/10.3389/fmicb.2020.00691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176365/
https://www.ncbi.nlm.nih.gov/pubmed/32351493
http://dx.doi.org/10.3389/fmicb.2020.00691

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