Lysis of membrane lipids promoted by small organic molecules: Reactivity depends on structure but not lipophilicity

Several organic molecules of low molecular weight (<150 Da) are demonstrated to have substantial membrane-lytic potential despite having a low predicted lipophilicity (logD < 1 at neutral pH). In aqueous liposome dispersions, 38 aromatic compounds were tested for their ability to either promot...

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Detalles Bibliográficos
Autores principales: Britt, Hannah M., Prakash, Aruna S., Appleby, Sanna, Mosely, Jackie A., Sanderson, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176411/
https://www.ncbi.nlm.nih.gov/pubmed/32426467
http://dx.doi.org/10.1126/sciadv.aaz8598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176411/
https://www.ncbi.nlm.nih.gov/pubmed/32426467
http://dx.doi.org/10.1126/sciadv.aaz8598

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