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Lysis of membrane lipids promoted by small organic molecules: Reactivity depends on structure but not lipophilicity
Several organic molecules of low molecular weight (<150 Da) are demonstrated to have substantial membrane-lytic potential despite having a low predicted lipophilicity (logD < 1 at neutral pH). In aqueous liposome dispersions, 38 aromatic compounds were tested for their ability to either promot...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176411/ https://www.ncbi.nlm.nih.gov/pubmed/32426467 http://dx.doi.org/10.1126/sciadv.aaz8598 |