FOXO1 deficiency impairs proteostasis in aged T cells

T cell differentiation involves the dynamic regulation of FOXO1 expression, which rapidly declines after activation and is subsequently restored. Reexpression is impaired in naïve CD4(+) T cell responses from older individuals. Here, we show that FOXO1 promotes lysosome function through the inductio...

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Detalles Bibliográficos
Autores principales: Jin, Jun, Li, Xuanying, Hu, Bin, Kim, Chulwoo, Cao, Wenqiang, Zhang, Huimin, Weyand, Cornelia M., Goronzy, Jorg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176426/
https://www.ncbi.nlm.nih.gov/pubmed/32494657
http://dx.doi.org/10.1126/sciadv.aba1808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176426/
https://www.ncbi.nlm.nih.gov/pubmed/32494657
http://dx.doi.org/10.1126/sciadv.aba1808

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