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FOXO1 deficiency impairs proteostasis in aged T cells
T cell differentiation involves the dynamic regulation of FOXO1 expression, which rapidly declines after activation and is subsequently restored. Reexpression is impaired in naïve CD4(+) T cell responses from older individuals. Here, we show that FOXO1 promotes lysosome function through the inductio...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176426/ https://www.ncbi.nlm.nih.gov/pubmed/32494657 http://dx.doi.org/10.1126/sciadv.aba1808 |