Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions

We report the in vivo regulation of Inosine-5´-monophosphate dehydrogenase 1 (IMPDH1) in the retina. IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleotides, impacting the cellular pools of GMP, GDP and GTP. Guanine nucleotide homeostasis is central to photoreceptor c...

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Detalles Bibliográficos
Autores principales: Plana-Bonamaisó, Anna, López-Begines, Santiago, Fernández-Justel, David, Junza, Alexandra, Soler-Tapia, Ariadna, Andilla, Jordi, Loza-Alvarez, Pablo, Rosa, Jose Luis, Miralles, Esther, Casals, Isidre, Yanes, Oscar, de la Villa, Pedro, Buey, Ruben M, Méndez, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176436/
https://www.ncbi.nlm.nih.gov/pubmed/32254022
http://dx.doi.org/10.7554/eLife.56418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176436/
https://www.ncbi.nlm.nih.gov/pubmed/32254022
http://dx.doi.org/10.7554/eLife.56418

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