Structural basis for ion selectivity in TMEM175 K(+) channels

The TMEM175 family constitutes recently discovered K(+)channels that are important for autophagosome turnover and lysosomal pH regulation and are associated with the early onset of Parkinson Disease. TMEM175 channels lack a P-loop selectivity filter, a hallmark of all known K(+) channels, raising th...

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Detalles Bibliográficos
Autores principales: Brunner, Janine D, Jakob, Roman P, Schulze, Tobias, Neldner, Yvonne, Moroni, Anna, Thiel, Gerhard, Maier, Timm, Schenck, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176437/
https://www.ncbi.nlm.nih.gov/pubmed/32267231
http://dx.doi.org/10.7554/eLife.53683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176437/
https://www.ncbi.nlm.nih.gov/pubmed/32267231
http://dx.doi.org/10.7554/eLife.53683

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