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Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses

Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), regulate long-term potentiation (LTP) in the hippocampus, although the sites of BDNF-TrkB receptors in this process are controversial. We used a viral-mediated approach to delete BDNF or Tr...

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Detalles Bibliográficos
Autores principales: Lin, Pei-Yi, Kavalali, Ege T., Monteggia, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176480/
https://www.ncbi.nlm.nih.gov/pubmed/30089265
http://dx.doi.org/10.1016/j.celrep.2018.07.020