Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics

Class III receptor tyrosine kinases control the development of hematopoietic stem cells. Constitutive activation of FLT3 by internal tandem duplications (ITD) in the juxtamembrane domain has been causally linked to acute myeloid leukaemia. Oncogenic FLT3 ITD is partially retained in compartments of...

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Detalles Bibliográficos
Autores principales: Kellner, Fabienne, Keil, Andreas, Schindler, Katrin, Tschongov, Todor, Hünninger, Kerstin, Loercher, Hannah, Rhein, Peter, Böhmer, Sylvia‐Annette, Böhmer, Frank‐D., Müller, Jörg P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176853/
https://www.ncbi.nlm.nih.gov/pubmed/32155324
http://dx.doi.org/10.1111/jcmm.15132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176853/
https://www.ncbi.nlm.nih.gov/pubmed/32155324
http://dx.doi.org/10.1111/jcmm.15132

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