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GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi

The integrated stress response in eukaryotic cells is an orchestrated pathway that leads to eukaryotic Initiation Factor 2 alpha subunit (eIF2α) phosphorylation at ser51 and ultimately activates pathways to mitigate cellular damages. Three putative kinases (Tck1, Tck2, and Tck3) are found in the Try...

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Detalles Bibliográficos
Autores principales: Malvezzi, Amaranta Muniz, Aricó, Mirella, Souza-Melo, Normanda, dos Santos, Gregory Pedroso, Bittencourt-Cunha, Paula, Holetz, Fabiola Barbieri, Schenkman, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176912/
https://www.ncbi.nlm.nih.gov/pubmed/32373547
http://dx.doi.org/10.3389/fcimb.2020.00149