Cargando…

Emerging New Concepts of Degrader Technologies

Traditional drug discovery focuses on identifying direct inhibitors of target proteins. This typically relies on a measurable biochemical readout and accessible binding sites whose occupancy influences the function of the target protein. These requirements preclude many disease-causing proteins from...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Yu, Fei, Yiyan, Lu, Boxun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177145/
https://www.ncbi.nlm.nih.gov/pubmed/32416934
http://dx.doi.org/10.1016/j.tips.2020.04.005